Journal
MEDICAL MOLECULAR MORPHOLOGY
Volume 47, Issue 2, Pages 63-67Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00795-013-0064-6
Keywords
Renal cell carcinoma; Metastasis; Heparanase; RANKL; Snail
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT) [25460422]
- MEXT [24390374, 24249022]
- Third Term 10-year Strategy for Cancer Control from the Foundation of Promotion of Cancer Research
- Project for Development of Innovative Research on Cancer Therapeutics (P-Direct) from MEXT
- Grants-in-Aid for Scientific Research [24390374, 25460422] Funding Source: KAKEN
Ask authors/readers for more resources
Renal cell carcinoma (RCC) represents over 80 % of kidney cancer, and about 30 % of the patients with RCC develop metastasis after the surgery. Invasion of basement membrane (BM) and extracellular matrix (ECM) is an essential event in tumor invasion and metastasis. Matrix metalloproteinases (MMPs), which digest the main components of BM and ECM, are expressed in RCC. Heparanase, which degrades heparan sulfate proteoglycans, is predominantly expressed in high-grade RCCs with a positive correlation with pathological tumor stage and poor prognosis. Bone metastasis is common among the patients with RCC, and increased osteoclastic activity was observed at metastatic sites. Receptor activator of nuclear factor kappa B ligand (RANKL), which plays an important role in osteoclastogenesis, is predominantly expressed in high-grade RCC and its expression level is associated with bone metastasis and prognosis. Epithelial-mesenchymal transition (EMT), a switch of epithelial cells to sarcomatoid phenotype, is considered to be critical step during metastasis, and Snail, a major regulator of EMT, is predominantly expressed in high-grade RCC, and high Snail expression is a worse prognostic factor. Accordingly, heparanase, RANKL and Snail may be targets for the development of anti-tumor therapies for RCCs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available