Journal
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Volume 201, Issue 4, Pages 487-495Publisher
SPRINGER
DOI: 10.1007/s00430-012-0263-0
Keywords
Mouse cytomegalovirus; NK cells; CD8(+) T cells; Ly49H
Categories
Funding
- NIH [1R01AI083201-01]
- Impuls- und Vernetzungsfonds of the Helmholtz Association [VH-VI-424-4]
- Federal Ministry of Education and Science
- Bosnia
- Herzegovina
Ask authors/readers for more resources
Natural killer (NK) cells play a crucial role in early immune response against cytomegalovirus infection. A large and mounting body of data indicate that these cells are involved in the regulation of the adaptive immune response as well. By using mouse cytomegalovirus (MCMV) as a model, several groups provided novel insights into the role of NK cells in the development and kinetics of antiviral CD8(+) T cell response. Depending on infection conditions, virus strain and the genetic background of mice used, NK cells are either positive or negative regulators of the CD8(+) T cell response. At present, there is no unique explanation for the observed differences between various experimental systems used. In this review we discuss the mechanisms involved in the interplay between NK and CD8(+) T cells in the early control of MCMV infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available