Journal
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Volume 197, Issue 2, Pages 75-82Publisher
SPRINGER
DOI: 10.1007/s00430-008-0087-0
Keywords
cytomegalovirus; sepsis; immunity; latency; reactivation; therapy; disease
Categories
Ask authors/readers for more resources
The human cytomegalovirus (HCMV) is a relevant pathogen in patients with immunosuppressive therapy; however, reactivation and subsequent recurrence occurs also in individuals without canonical immunosuppression as e.g., in patients with septic shock. Analyzing the impact of NK- and T-cell immunity on the natural course of HCMV infection in patients with septic shock, it became clear that the presence of HCMV reactive T-helper cells did not prevent the development of reactivation but, the control of active infection was achieved mostly by specific T-cells. NK-cells seemed to be dispensable for clearance of active infection in this patient group with long-lasting NK-cell anergy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available