4.5 Article

The potential role of microRNA-146 in Alzheimer's disease: Biomarker or therapeutic target?

Journal

MEDICAL HYPOTHESES
Volume 78, Issue 3, Pages 398-401

Publisher

CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2011.11.019

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Funding

  1. National Basic Research Development Program of China [2010CB945200]
  2. Shanghai Key Discipline Program [S30202]
  3. Shanghai Key Project of Basic Science Research [09DZ1950400]
  4. Program for Outstanding Medical Academic Leader [Lj 06003]

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Recently, there have been increasing evidences that microRNA-146 (miR-146) is related to up-regulated immune and inflammatory signaling through its target genes, such as IRAK1 and TRAF6. Additionally, abundant data continue to support the hypothesis that progressive up-regulation of inflammatory gene expression and elevated inflammatory signaling facilitate the development and progression of Alzheimer's disease (AD). This review focuses on the recent findings regarding the role of miR-146 in modulating immune response and its subsequent effects in the pathogenesis of AD. (C) 2011 Elsevier Ltd. All rights reserved.

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