Journal
MEDICAL HYPOTHESES
Volume 76, Issue 5, Pages 643-645Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2011.01.021
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The pathogenesis of amyotrophic lateral sclerosis (ALS) is multifactorial and a treatment targeting only one aspect of the disease is unlikely to be beneficial. Vitamin D is safe and may delay progression of ALS by acting on several aspects of the disease. In this article we explore how vitamin D may promote VGEF, IGF-1 and axonal regeneration delaying ALS progression. In addition, we discuss how vitamin D may increase calcium binding protein in motor neuron cells conferring a greater resistance to the underlying disease process, as seen in the oculomotor nerve and Onuf's nucleus. Finally, we discuss vitamin D immunomodulator role, decreasing the reactive gliosis in ALS. (C) 2011 Elsevier Ltd. All rights reserved.
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