Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer

Oral lichen planus (OLP) is a chronic inflammatory disease, which has been defined by the World Health Organization as a potential precancerous condition, representing a generalized state associated with a significantly increased risk of oral cancer. We would like to put forward a hypothesis that inflammatory mediators such as cytokines and chemokines released from infiltrating T lymphocytes induce fundamental changes of proteins in oral epithelial cells, leading to the progression of OLP to oral squamous cell carcinoma (OSCC). These altered proteins can act as the key risk factors associated with the local microenvironment and development of OSCC. Identification of these proteins would add to our understanding of the connection between chronic inflammation and OSCC. (C) 2010 Elsevier Ltd. All rights reserved.