The failure of HIV vaccines: A new autovaccine may overcome some problems

The hypothesis of an autovaccine for HIV is borne out by: (1) the present lack of a valid vaccine; (2) by a remarkable improvement of the HAART, which however does not prevent HIV mutagenicity and a consequent valid immunological response and (3) the persistence of a hidden infection ready to thrive again. The preparation of the autovaccine is described as well as the administration schedule but only a clinical study will define its validity. (C) 2009 Elsevier Ltd. All rights reserved.