Journal
MEDICAL ENGINEERING & PHYSICS
Volume 35, Issue 6, Pages 723-735Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2012.07.015
Keywords
Magnetic resonance imaging (MRI); Congenital heart disease; Phase-contrast MRI; Bicuspid aortic valve; Kinetic energy; Shear stress; Hemodynamics; Turbulence
Categories
Funding
- American Heart Association Predoctoral Fellowship award [0810093Z]
- Alvin and Marion Birnschein Foundation
- NIH [R15HL096096-01]
- National Science Foundation [OCI-0923037, CBET-0521602]
Ask authors/readers for more resources
Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse flow patterns contributing to morbidity. Our objectives were to develop a method to account for the AoV in CFD simulations, and quantify its impact on local hemodynamics. The method developed facilitates segmentation of the AoV, spatiotemporal interpolation of segments, and anatomic positioning of segments at the CFD model inlet. The AoV was included in CFD model examples of a normal (tricuspid AoV) and a post-surgical CoA patient (BAV). Velocity, turbulent kinetic energy (TKE), time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) results were compared to equivalent simulations using a plug inlet profile. The plug inlet greatly underestimated TKE for both examples. TAWSS differences extended throughout the thoracic aorta for the CoA BAV, but were limited to the arch for the normal example. OSI differences existed mainly in the ascending aorta for both cases. The impact of AoV can now be included with CFD simulations to identify regions of deleterious hemodynamics thereby advancing simulations of the thoracic aorta one step closer to reality. (C) 2012 IPEM. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available