Journal
MEDICAL ENGINEERING & PHYSICS
Volume 35, Issue 9, Pages 1349-1357Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2013.03.006
Keywords
Differential impedance analysis (DIA); Fricke-Morse model; Complex nonlinear least square (CNLS); Electrical bioimpedance (EBI); Electrical impedance spectroscopy (EIS)
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Funding
- Spanish Ministry of Science and Innovation, Redes de Investigacion del Instituto de Salud Carlos III (REDINSCOR) [RD06/0003]
- Fondo Europeo de Desarollo Regional (FEDER)
- Spanish Ministry MICINN [SAF2008-05144-C02-02, SAF2011-30067-C02-02]
- Fund for Scientific Research (FWO-Vlaanderen)
- Flemish Government (Methusalem)
- Belgian Government through the Interuniversity Poles of Attraction (IAP VII) Program
- European Union
- MWIFT-NRW (Hightech.NRW competition)
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The goal of this manuscript is to present a new methodology for real time analysis of time-varying electrical bioimpedance data. The approach assumes that the Fricke-Morse model of living tissues is meaningful and valid within the measured frequency range (10 kHz to 1 MHz). The parameters of this model are estimated in the whole frequency range with the presented method based on differential impedance analysis (DIA). The numerical accuracy of the developed approach has been validated and compared to complex nonlinear least square (CNLS) approach through simulations and also with experimental data from in vivo time-varying human lung tissue bioimpedance. The new developed method has demonstrated a promising performance for fast and easily interpretable information in real time. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.
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