Journal
MEDICAL ENGINEERING & PHYSICS
Volume 34, Issue 6, Pages 762-776Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2012.05.008
Keywords
Additive manufacture; Triply periodic minimal surface; Distance fields; 3D tissue scaffolds; Freeform fabrication tool path
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Funding
- Daejin University
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Advanced additive manufacture (AM) techniques are now being developed to fabricate scaffolds with controlled internal pore architectures in the field of tissue engineering. In general, these techniques use a hybrid method which combines computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to design and fabricate complicated three-dimensional (3D) scaffold models. The mathematical descriptions of micro-architectures along with the macro-structures of the 3D scaffold models are limited by current CAD technologies as well as by the difficulty of transferring the designed digital models to standard formats for fabrication. To overcome these difficulties, we have developed an efficient internal pore architecture design system based on triply periodic minimal surface (TPMS) unit cell libraries and associated computational methods to assemble TPMS unit cells into an entire scaffold model. In addition, we have developed a process planning technique based on TPMS internal architecture pattern of unit cells to generate tool paths for freeform fabrication of tissue engineering porous scaffolds. (C) 2012 IPEM. Published by Elsevier Ltd. All rights reserved.
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