Journal
MEDICAL DOSIMETRY
Volume 38, Issue 4, Pages 390-394Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.meddos.2013.05.001
Keywords
Proton therapy; Spot scanning; Single field uniform dose optimization; Radiation therapy; Head and neck malignancies
Funding
- National Cancer Institute [P01CA021239]
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Radiation therapy for head and neck malignancies can have side effects that impede quality of life. Theoretically, proton therapy can reduce treatment-related morbidity by minimizing the dose to critical normal tissues. We evaluated the feasibility of spot-scanning proton therapy for head and neck malignancies and compared dosimetry between those plans and intensity-modulated radiation therapy (IMRT) plans. Plans from 5 patients who had undergone IMRT for primary tumors of the head and neck were used for planning proton therapy. Both sets of plans were prepared using computed tomography (Cl') scans with the goals of achieving 100% of the prescribed dose to the clinical target volume (CTV) and 95% to the planning TV (PTV) while maximizing cohformity to the PTV. Dose-volume histograms were generated and compared, as were conformity indexes (Cls) to the PTVs and mean doses to the organs at risk (OARs). Both modalities in all cases achieved 100% of the dose to the CTV and 95% to the PTV. Medd PTV CIs were coMparable (0.371 WIRT, 0.374 proton; p = 0.953). Mean doses were significantly lower In the proton plans to the contralateral submandibular (638.7 cGy IMRT, 4.3 cGy protons, /3 = 0.002) and parotid (533.3 cGy IMRT, 48.5 cGy protons, p = 0.003) glands; oral cavity (1760.4 cGy IMRT, 458.9 cGy protons, p = 0.003); spinal cord (2112.4 cGy IMRT, 249.2 cGy Protons, p = 0.002); and brainStem (1553.5/ cGy IMRT, 166.2 cGy protons, p = 0.005). Proton plans also produced lower maximum doses to the spinal cdrd (3692.1 cGy IMRT, 2014.8 cGy protons, p = 0.034) and brainstem (3412.1 cGy IMRT, 1387.6 cGy protons, p -= 0.00). Normal tissue V-10, V-30, and V-50 values were also significantly lower in the proton plans. We conclude that spot-scanning proton therapy can significantly reduce the integral dose to head and neck critical structures. Prospective studies are underway to determine if this reduced dose translates to improved quality of life. (C) 2013 American Association of Medical Dosimetrists.
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