Journal
MEDICAL CLINICS OF NORTH AMERICA
Volume 95, Issue 5, Pages 953-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2011.06.007
Keywords
Exercise; Skeletal muscle; Insulin resistance; Substrate metabolism; Gene expression; AMPK
Categories
Funding
- Swedish Research Council
- Novo Nordisk Foundation
- Hedlunds Foundation
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Lifestyle intervention programs encompassing exercise and healthy diets are an option for the treatment and management of obesity and type 2 diabetes and have long been known to exert beneficial effects on whole-body metabolism, in particular leading to enhanced insulin-sensitivity. Obesity is associated with increased risk of several illnesses and premature mortality. However, physical inactivity is itself associated with a number of similar risks, independent of body-mass index, and is an independent risk factor for more than 25 chronic diseases, including type 2 diabetes and cardiovascular disease. This article addresses the debate regarding the relative effects of physical exercise itself and the effect of exercise-induced weight loss.
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