Journal
MEDICAL CLINICS OF NORTH AMERICA
Volume 94, Issue 4, Pages 711-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2010.04.001
Keywords
Drug hypersensitivity; Cutaneous manifestation; Maculopapular exanthem; Urticaria; Vasculitis; Acute generalized exanthematous pustulosis; Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms
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Drugs may elicit a considerable variety of clinical signs, often affecting the skin and the mucous membranes. The most common are maculopapular exanthemas and urticaria, more rarely pustules, bullae vasculitic lesions, and lichenoid lesions may also be observed. Apart from the morphology, the chronology of the occurrence and the evolution of single skin lesions and exanthema are also paramount in the clinical diagnosis of cutaneous drug hypersensitivity. Often, the skin represents the only organ manifestation; however, it may be the herald for a systemic involvement of internal organs, such as in severe drug-induced hypersensitivity syndromes or anaphylaxis.
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