Journal
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
Volume 48, Issue 9, Pages 837-844Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11517-010-0659-1
Keywords
Bioelectrics; Nanosecond pulsing; Electroporation; Modeling; Pore shape
Categories
Funding
- ORSP of Central Michigan University
Ask authors/readers for more resources
Cell membrane permeabilization mechanics and the resulting shape of nanopores in response to electrical pulsing are probed based on a continuum approach. This has implications for electropermeabilization and cell membrane transport. It is argued that small pores resulting from high-intensity (similar to 100 kV/cm), nanosecond pulsing would have an initial asymmetric shape. This would lead to asymmetric membrane current-voltage characteristics, at least at early times. The role of the cytoskeleton is ignored here, but can be expected to additionally contribute to such asymmetries. Furthermore, we show that the pore shape and membrane conduction would be dynamic, and evolve toward a symmetric characteristic over time. This duration has been shown to be in the micro-second range.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available