Journal
MEDIATORS OF INFLAMMATION
Volume 2014, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2014/320906
Keywords
-
Categories
Funding
- Ministry of Economy (Project SAF) [2010/16024, SAF-2013-44416-R]
- Institute Carlos III (RETICS) [RD12/0034/0003]
- Instituto de Salud Carlos III, Spain [FIS PI11/01601]
- Generalitat de Catalunya [2009SGR869]
- Spanish Ministry of Economy (FEDER-CICYT) [MAT2010-20452-C03-01]
Ask authors/readers for more resources
Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly tuned, can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P-1, P-4-diadenosine tetraphosphate (Ap(4)A), and P-1,P-5-diadenosine pentaphosphate (Ap(5)A) are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A(2A) adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A(3) receptor, selective agonists like N-6-(3-iodobenzyl)-5'. -N-methylcarboxamidoadenosine (CF101) have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases) can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available