Journal
MEDIATORS OF INFLAMMATION
Volume 2012, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/639735
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Objective. Discuss the changes and roles of PAF in the reproductive tract infection by observing the expression of platelet activating factor (PAF) and tumor necrosis factor alpha (TNF-alpha) in seminal plasma of patients with leukocytospermia. Methods. The seminal plasma was obtained from 22 cases of leukocytospermia and 15 cases of normal males; the peroxidase dyeing method was adopted for seminal plasma white blood count; the ELISA was adopted to test PAF and TNF-alpha concentration in seminal plasma. Result. PAF concentration (2.14 +/- 0.43 ng/mL) of leukocytospermia group was significantly lower than the normal group (6.21 +/- 1.38 ng/mL, P < 0.01) while TNF-alpha (5.51 +/- 1.46 ng/mL) was significantly higher than that of normal group (3.48 +/- 1.08 ng/mL). There was negative correlation between PAF and TNF-alpha, (r = -0.68, P < 0.01); the same situation existed in PAF and WBC (r = -0.62, P < 0.01); but TNF-alpha was positively correlated to WBC (r = 0.77, P < 0.01). Conclusion. (1) Low expression of PAF and high expression of TNF-alpha in leukocytospermia affect the sperm motility, which is one of the reasons that leads to infertility. (2) Lower expression of PAF has its particularity during the reproductive tract infection.
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