Journal
MECHANISMS OF DEVELOPMENT
Volume 133, Issue -, Pages 117-125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2014.05.002
Keywords
Drosophila; Hedgehog; Hyperplastic discs; Ubiquitination; Transcription
Categories
Funding
- National Basic Research Program of China [2011CB943901, 2011 CB943902, 2011 CB943802]
- National Natural Science Foundation of China [31030049]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01010101]
- NIH [2R01GM063891, 1R01GM087517]
Ask authors/readers for more resources
Hedgehog (Hh) acts as a morphogen to activate the transcription of diverse target genes via its downstream effector Cubitus interruptus (Ci). Currently, it is less understood how Ci recruits co-factors to activate transcription. Here we report that hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes. Importantly, Hyd does not affect the stability of Ci. Our data suggest that Hyd differentially restrains the transcriptional activity of Ci via selective association with respective promoters. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available