Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 138, Issue -, Pages 53-58Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2014.01.007
Keywords
Nar1; Lifespan; Mitochondrial superoxide dismutase
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Funding
- National Natural Science Foundation of China [30871440, 31101051, 81170327]
- Natural Science Foundation of Guangdong Province [9252402301000002]
- Technology Planning Project for University Research Institutions and Medical and Health Organizations of Dongguan City [2012108102022]
- Science & Technology Innovation Fund of Guangdong Medical College [STIF201102]
- Ph.D. Start-up Fund of Guangdong Medical College [B2012061]
- NIH Training Grant [T32AG000057, T32ES007032]
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Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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