Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 134, Issue 5-6, Pages 202-211Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2013.02.004
Keywords
ATP-dependent chromatin remodeling; CSB; DNA repair; Transcription regulation; Chromatin
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Funding
- US National Institutes of Health [GM 084983]
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The Cockayne syndrome complementation group B protein, CSB, plays pivotal roles in transcription regulation and DNA repair. CSB belongs to the SNF2/SWI2 ATP-dependent chromatin remodeling protein family, and studies from many laboratories have revealed that CSB has multiple activities and modes of regulation. To understand the underlying mechanisms of Cockayne syndrome, it is necessary to understand how the biochemical activities of CSB are used to carry out its biological functions. In this review, we summarize our current knowledge of the structure, function and regulation of CSB, and discuss how these properties can impact the biological functions of this chromatin remodeler. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
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