Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 133, Issue 11-12, Pages 655-664Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2012.09.001
Keywords
Aging; Skeletal muscle; AMPK; mTOR; Resistance exercise
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Funding
- National Institutes of Health [RO1-DK80157, RO1-DK089229]
- Paul B. Beeson Career Development Award from the American Federation for Aging Research and the National Institute on Aging [K23-AG030979]
- Anna Foundation (Leiden, the Netherlands)
- U.K. Medical Research Council
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AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPK alpha 2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPK alpha 1 activity in older men, however, AMPK alpha 2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity. Published by Elsevier Ireland Ltd.
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