Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 131, Issue 7-8, Pages 503-510Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2010.04.009
Keywords
Mitochondrial DNA; Helicases; BER; Aging; mtDNA deletions
Categories
Funding
- FAPESP
- Instituto Nacional de Ciencia e Tecnologia (INCT) Processos Redox em Biomedicina - CNPq/FAPESP
- European Commission [LSHM-CT-2004-512020]
- VELUX foundation [95-103-11419]
- Danish Cancer Society [DP05118, DP03131]
- Danish Research Council [271-08-0697]
- Lundbeck Foundation
- National Institute on Aging, National Institutes of Health
- Lundbeck Foundation [R5-2006-128] Funding Source: researchfish
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Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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