Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 131, Issue 2, Pages 165-167Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2009.12.009
Keywords
Biomarkers of aging; Anti-aging; Physical activity; Human
Categories
Funding
- National Institutes of Health [AG013038, AG006537, AG022241, AG015897, AG031141, AG000279, RR00051]
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Telomere length (TL), a measure of replicative senescence, decreases with aging, but the factors involved are incompletely understood. To determine if age-associated reductions in TL are related to habitual endurance exercise and maximal aerobic exercise capacity (maximal oxygen consumption, VO(2)max), we studied groups of young (18-32 years; n = 15,7 male) and older (55-72 years; n = 15,9 male) sedentary and young (n = 10,7 male) and older (n = 17,11 male) endurance exercise-trained healthy adults. Leukocyte TL (LTL) was shorter in the older (7059 +/- 141 bp) vs. young (8407 +/- 218) sedentary adults (P < 0.01). LTL of the older endurance-trained adults (7992 +/- 169 bp) was 900 bp greater than their sedentary peers (P < 0.01) and was not significantly different (P = 0.12) from young exercise-trained adults (8579 +/- 413). LTL was positively related to VO(2)max as a result of a significant association in older adults (r = 0.44, P < 0.01). Stepwise multiple regression analysis revealed that VO(2)max was the only independent predictor of LTL in the overall group. Our results indicate that LTL is preserved in healthy older adults who perform vigorous aerobic exercise and is positively related to maximal aerobic exercise capacity. This may represent a novel molecular mechanism underlying the anti-aging effects of maintaining high aerobic fitness. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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