Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 131, Issue 7-8, Pages 451-462Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2010.03.007
Keywords
Aging; Mitochondria; Mitochondrial DNA
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Funding
- NIH [R01-AG09531, UL1-RR024150, T32-DK07352]
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Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondria! DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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