Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 131, Issue 7-8, Pages 511-516Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2010.05.001
Keywords
Sirtuins; Mitochondria; AceCS2; Acetate; Aging
Categories
Funding
- Elison Medical Foundation
- J. David Gladstone Institutes
Ask authors/readers for more resources
Sirtuins are NAD(+)-dependent protein deacetylases that regulate gene silencing, energy metabolism and aging from bacteria to mammals. SIRT3, a mammalian mitochondrial sirtuin, deacetylates acetyl-CoA synthetase (AceCS2) in the mitochondria. AceCS2 is conserved from bacteria to humans, catalyzes the conversion of acetate to acetyl-CoA and enables peripheral tissues to utilize acetate during fasting conditions. Here, we review the regulation of acetate metabolism by sirtuins, the remarkable conservation of this metabolic regulatory pathway and its emerging role in the regulation of aging and longevity. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available