Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 130, Issue 9, Pages 648-651Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2009.06.007
Keywords
Differential gene expression; Human diploid fibroblasts; Lysophosphatidic acid; cDNA microarray analysis; Senescent HDFs
Categories
Funding
- Korea Research Foundation for Health Science
- Korea Science and Engineering Foundation (KOSEF)
- Center for Ageing and Apoptosis Research at Seoul National University [RII-2002-097-08003-0, RII-2002-097-08001-0]
- Korea Basic Science Institute (K-MeP)
Ask authors/readers for more resources
The gene expression profiles of lysophosphatidic acid (LPA)-treated young and senescent human diploid fibroblasts (HDFs) were examined using cDNA microarray analysis. The expression of some genes, including EGR 1/3 and MRRF, was controlled by LPA similarly in young and senescent cells, showing a typical time-dependent up-and-down expression profile. In contrast, some other genes, including DUSP6, CYR61, and F3, showed sustained upregulation in senescent HDFs later after LPA treatment. These genes might be involved in altered LPA responsiveness during the aging process. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
