Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 129, Issue 7-8, Pages 467-474Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2008.04.001
Keywords
cellular senescence; aging; telomeres
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Funding
- NIA NIH HHS [R01 AG 016694, R01 AG016694, R01 AG016694-09] Funding Source: Medline
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Cellular senescence, first observed and defined using in vitro cell culture studies, is an irreversible cell cycle arrest which can be triggered by a variety of factors. Emerging evidence suggests that cellular senescence acts as an in vivo tumor suppression mechanism by limiting aberrant proliferation. It has also been postulated that cellular senescence can occur independently of cancer and contribute to the physiological processes of normal organismal aging. Recent data have demonstrated the in vivo accumulation of senescent cells with advancing age. Some characteristics of senescent cells, such as the ability to modify their extracellular environment, could play a role in aging and age-related pathology. In this review, we examine current evidence that links cellular senescence and organismal aging. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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