Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 129, Issue 5, Pages 271-281Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2008.01.009
Keywords
vaccination; mucosa; memory
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Funding
- NIAID NIH HHS [P01 AI060642-03, P01 AI060642] Funding Source: Medline
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We evaluated the ability of flagellin, a highly effective mucosal adjuvant in mice and non-human primates, to promote mucosal innate and adaptive immunity in aged mice. We found that intratracheal instillation of flagellin induced a stronger respiratory innate response in aged mice than in young mice, and that intranasal instillation of flagellin was equally effective at triggering recruitment of T and B lymphocytes to the draining lymph nodes of young and aged mice. Intranasal immunization of aged mice with flagellin and the Yersinia pestis protein F1 promoted specific IgG and IgA production, but at lower levels and lower avidities than in young mice. Although intranasal instillation of flagellin and F1 antigen increased germinal center formation and size in young mice, it did not do so in aged mice. Our findings are consistent with the conclusion that flagellin can promote adaptive immune responses in aged mice, but at a less robust level than in young mice. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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