Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 129, Issue 1-2, Pages 91-98Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2007.10.008
Keywords
human telomerase; telomerase RNA; telomerase reverse transcriptase; ribonucleoprotein; biogenesis; dyskeratosis congenita
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL079585] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM054198] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL079585, R01 HL079585-03] Funding Source: Medline
- NIGMS NIH HHS [R01 GM054198, R01 GM054198-11] Funding Source: Medline
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Telomerase is a specialized reverse transcriptase conserved throughout almost all eukaryotic life. It plays a fundamental role in genome maintenance, adding back the telomeric DNA repeats lost from chromosome ends due to incomplete replication or damage. The protein and RNA subunits of telomerase fold and function in a co-dependent manner to establish a high fidelity of telomeric repeat synthesis. Over the past two decades, studies of telomerase have uncovered previously unanticipated levels of complexity in its assembly, activity and regulation. This review describes the current understanding of telomerase in humans, with particular focus on telomerase biogenesis and regulation in its cellular context. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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