Journal
MEAT SCIENCE
Volume 95, Issue 1, Pages 64-71Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.meatsci.2013.04.021
Keywords
ACACA; SREBF1; Pig; Fatty acids; SNP; Transcription
Categories
Funding
- Polish Ministry of Science and Higher Education [N N311 288936]
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Among functional and positional candidate genes for pig fatness traits, there are genes encoding acetyl-CoA carboxylase alpha (ACACA) and sterol regulatory element binding transcription factor 1 (SREBF1). In our study, 5 known and 2 novel SNPs in the ACACA gene and 2 known and 6 novel polymorphisms in the SREBF1 were found. The SNPs segregated as 6 and 10 haplotypes in ACACA and SREBF1, respectively. Two SNPs in ACACA were associated with fatness and performance traits in Polish breeds. In the SREBF1 gene, two novel SNPs were associated with daily gain and one, within a potential intronic micro-RNA gene, showed an association with fatness traits. Breed-specific differences in the transcript level were observed for ACACA only. No correlation between the transcript levels and fatty add compositions was found in muscle and fat tissues. We concluded that polymorphisms of the ACACA and SREBF1 genes are promising markers for pig carcass and performance traits. (c) 2013 Elsevier Ltd. All rights reserved.
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