Journal
APPLIED SURFACE SCIENCE
Volume 352, Issue -, Pages 117-125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2015.03.137
Keywords
Glucose polymers; Magnetic nanoparticles; Cytotoxicity; Magnetic hyperthermia; Hydrothermal
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This study reports an approach for a facile one-step synthesis of magnetic nanoparticles (MNPs) coated with glucose-derived polymers (GDP) through a mechanochemical hydrothermal process for biomedical applications. Polymer-coated magnetic nanoparticles (Fe2O3/Fe3O4), with sizes below 10 nm, exhibited superparamagnetic behavior, with a specific magnetization saturation value of about 40 emu/g, and a maximum specific absorption rate (SAR) of 30 W/g in AC magnetic fields. Depending on the intensity of the applied AC magnetic field, a temperature of 42 degrees C can be achieved in 4-17 min. The surface polymerized layer affords functional hydroxyl groups for binding to biomolecules containing carboxyl, thiol, or amino groups, thereby making the coated nanoparticles feasible for bio-conjugation. In vitro cytotoxicity evaluation pointed out that a relatively high concentration of polymer-coated magnetic nanoparticles (GDP-MNPs) did not induce severe cell alteration, suggesting a good biocompatibility. (C) 2015 Elsevier B.V. All rights reserved.
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