Journal
MEASUREMENT SCIENCE AND TECHNOLOGY
Volume 23, Issue 6, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-0233/23/6/062001
Keywords
ultrafast; spectroscopy; infrared; molecular dynamics; biological chemistry; biophysics
Funding
- European research Council [20270]
- Leverhulme Trust
- Diamond Light Source
- Strathclyde Knowledge Transfer Account
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Recent advances in the methodology and application of ultrafast two-dimensional infrared (2D-IR) spectroscopy to biomolecular systems are reviewed. A description of the 2D-IR technique and the molecular contributions to the observed spectra are presented followed by a discussion of recent literature relating to the use of 2D-IR and associated approaches for measuring protein dynamics. In particular, these include the use of diatomic ligand groups for measuring haem protein dynamics, isotopic labelling strategies and the use of vibrational probe groups. The final section reports on the current state of the art regarding the use of 2D-IR methods to provide insights into biological reaction mechanisms.
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