Journal
MEASUREMENT SCIENCE AND TECHNOLOGY
Volume 22, Issue 10, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/0957-0233/22/10/104015
Keywords
scale-up; pharmaceutical fluidized bed; ECT; CFD
Funding
- EPSRC [GR/T29383/01, GR/T29376/01, EP/G005702/1, EP/H502327/1]
- University of Manchester Intellectual Property (UMIP) Ltd
- National Natural Foundation of China [61072001, 50876102]
- Engineering and Physical Sciences Research Council [GR/T29376/01, GR/T29383/01, EP/H502327/1, EP/G005702/1] Funding Source: researchfish
- EPSRC [EP/G005702/1, EP/H502327/1] Funding Source: UKRI
Ask authors/readers for more resources
The aim of this research is to apply electrical capacitance tomography (ECT) in pharmaceutical fluidized beds and scale up the application of ECT from a lab-scale fluidized bed to a production-scale fluidized bed. The objective is to optimize the design of the production-scale fluidized bed and to improve the operation efficiency of the fluidization processes. This is the first time that ECT has been scaled up to a production-scale fluidized bed of 1.0 m diameter and batch process capacity of 100 kg in a real industrial environment. With a large-scale fluidized bed in a real industrial environment, some key issues on the ECT sensor design must be addressed. To validate ECT measurement results, a two-phase flow model has been used to simulate the process in a lab-scale and pilot-scale fluidized bed. The key process parameters include solid concentration, average concentration profiles, the frequency spectrum of signal fluctuation obtained by the fast Fourier transfer (FFT) and multi-level wavelet decomposition in the time domain. The results show different hydrodynamic behaviour of fluidized beds of different scales. The time-averaged parameters from ECT and computational fluid dynamics are compared. Future work on the ECT sensor design for large-scale fluidized beds are given in the end of the paper.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available