Journal
MATURITAS
Volume 72, Issue 3, Pages 214-219Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2012.04.010
Keywords
Endometriosis; Menopause; Postmenopausal; Pathophysiology
Categories
Funding
- MRC [G0601458]
- Oxford Partnership Comprehensive Biomedical Research Centre
- Department of Health's NIHR Biomedical Research Centres scheme
- MRC [G0601458] Funding Source: UKRI
- Medical Research Council [G0601458] Funding Source: researchfish
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Endometriosis is a chronic gynaecological disorder, the cause of which remains a subject of controversy. Oestrogen dependence is considered central to development and progression, and endometriosis is widely viewed as a disease of the premenopausal years, which normally regresses during the menopause. Increasingly however, reports of cases of postmenopausal endometriosis challenge our current understanding of the pathophysiology and raise further questions concerning the processes involved. Exploring the limited evidence available on postmenopausal disease we attempt to draw comparisons with premenopausal endometriosis, and in doing so to propose mechanisms for postmenopausal disease that are compatible with our current general understanding of the condition. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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