Journal
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
Volume 48, Issue 5, Pages 617-621Publisher
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0017-2015
Keywords
VRE; Biofilm; Expression
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Introduction: Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome. Methods: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin. Results: A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro. Conclusions: Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.
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