Journal
MATURITAS
Volume 65, Issue 4, Pages 334-339Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2009.12.019
Keywords
Bioavailability; Metabolism; Phytoestrogens; Menopause
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- University Pierre et Marie Curie
- Institut Curie (France)
- Fonds J.-C. Heuson de Recherche en Cancerologie Mammaire (Belgium)
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It has been proposed that the use of phytoestrogens (PE) in menopausal therapy could be beneficial to woman health, particularly with respect to hot flushes. Indeed, PE may compensate the lack of endogenous 17 beta-estradiol occurring during menopause. However, therapeutic benefits remain questionable, as highlighted by recent publications. Indeed, data are often subjected to controversy since a number of exogenous and endogenous factors influencing the responsiveness of patients are not sufficiently taken into account. In the present paper, we will discuss the role of bioavailability and metabolism in the instability of individual response to PE. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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