Journal
MATRIX BIOLOGY
Volume 75-76, Issue -, Pages 1-11Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2018.08.007
Keywords
Proteoglycans; Collagens; Proteases; Senescence; Cancer
Categories
Funding
- National Institutes of Health [CA39481, CA47282]
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The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease. (C) 2018 Elsevier B.V. All rights reserved.
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