Journal
MATRIX BIOLOGY
Volume 39, Issue -, Pages 44-49Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2014.08.015
Keywords
Progenitors; Chondroprogenitors; Articular cartilage; Injury; Repair
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Funding
- National Institute of Health [AR46000, AG025868]
- Children's Hospital of Philadelphia
- Japan Society for the Promotion of Science (JSPS) [24791983]
- Grants-in-Aid for Scientific Research [24791983] Funding Source: KAKEN
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Articular cartilage has poor capacity of self-renewal and repair. Insufficient number and activity of resident mesenchymal (connective tissue) progenitors is likely one of the underlying reasons. Chondroprogenitors reside not only in the superficial zone of articular cartilage but also in other zones of articular cartilage and in the neighboring tissues, including perichondrium (groove of Ranvier), synovium and fat pad. These cells may respond to injury and contribute to articular cartilage healing. In addition, marrow stromal cells can migrate through subchondral bone when articular cartilage is damaged. We should develop drugs and methods that correctly stimulate resident progenitors for improvement of repair and inhibition of degenerative changes in articular cartilage. (C) 2014 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
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