Journal
MATRIX BIOLOGY
Volume 37, Issue -, Pages 131-141Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2014.03.001
Keywords
Osteopontin; Matricellular; Cancer; Isoforms; Signaling
Categories
Funding
- NCI NIH HHS [R01 CA138850, R01CA138850, R01CA140472, R01 CA140472] Funding Source: Medline
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Osteopontin (OPN) is a multifunctional cytokine that impacts cell proliferation, survival, drug resistance, invasion, and stem like behavior. Due to its critical involvement in regulating cellular functions, its aberrant expression and/or splicing is functionally responsible for undesirable alterations in disease pathologies, specifically cancer. It is implicated in promoting invasive and metastatic progression of many carcinomas. Due to its autocrine and paracrine activities OPN has been shown to be a crucial mediator of cellular cross talk and an influential factor in the tumor microenvironment. OPN has been implicated as a prognostic and diagnostic marker for several cancer types. It has also been explored as a possible target for treatment. In this article we hope to provide a broad perspective on the importance of OPN in the pathophysiology of cancer. Published by Elsevier B.V.
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