Journal
REVIEWS IN MEDICAL VIROLOGY
Volume 25, Issue 6, Pages 431-445Publisher
WILEY
DOI: 10.1002/rmv.1858
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Funding
- Central South University for Forestry and Technology [2013WK4006]
- grain-oil process and quality control collaborative and innovative grant from Hunan Province
- Central South University for Forestry and Technology
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Resveratrol is a natural phenolic product found in some plants in response to stress and has been linked to the many health benefits of red wine. Over the past several decades, a great deal of research has identified diverse biological roles associated with resveratrol, including anti-oxidant, anti-proliferation, anti-inflammation, anti-cancer, anti-fungal, and antiviral activities. Such biological activities of resveratrol are likely mediated through multiple cellular targets or pathways, such as sirtuins, a family of NAD(+)-dependent deacetylases. In this treatise, the literatures focusing on the roles of resveratrol and sirtuins in modulating infections by a broad-spectrum of viruses are reviewed, with an emphasis on its potential antiviral mechanisms. A working model about the effects of resveratrol on virus infection is proposed to stimulate further researches on this exciting topic. Copyright (c) 2015 John Wiley & Sons, Ltd.
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