Journal
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Volume 35, Issue 3, Pages 537-546Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0000000000000341
Keywords
chorioretinal anatomosis; Coats disease; Doppler optical coherence tomography; retinal-choroidal anastomosis; retinal angiomatous proliferation
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Funding
- Baptist Foundation, Memphis, TN
- Research to Prevent Blindness, Tarrytown, NY
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Purpose: To describe the structural characteristics of retinal angiomatous proliferation and chorioretinal anastomosis in childhood Coats disease and redefine the previously described macular fibrosis. Methods: Prospective observational case series of consecutive patients with Coats disease examined over a 1-year study period. Multimodal imaging, including color fundus photography, wide-field fluorescein angiography, and spectral domain optical coherence tomography, was used to identify the features of macular retinal angiomatous proliferation and chorioretinal anastomosis. Results: Retinal angiomatous proliferation and chorioretinal anastomosis were present in 5 of 21 patients with Coats disease (24%). The lesions appeared as well demarcated, nodular retinal pigment epithelial detachments surrounded by exudate, with retinal vessels continuous with the underlying choroidal neovascularization. Conclusion: Retinal angiomatous proliferation and chorioretinal anastomoses are features observed in a number of children (24% in the present series) with Coats disease and macular involvement. This lesion represents a distinct macular variant of Coats disease that underlies at least a proportion (all in the present series) of the previously described macular fibrosis and subretinal mounds.
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