Journal
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
Volume 176, Issue 20, Pages 1835-1840Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mseb.2011.02.010
Keywords
Magnesium; Biodegradable; Corrosion; Histology; Synchrotron-radiation based micro-computed tomography; Implants
Funding
- BMBF
- TUBITAK
- [II-20090232]
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The corrosion of biodegradable materials is a crucial issue in implant development. Among other materials, magnesium and magnesium based alloys are one of the most promising candidates. Since the corrosion of biodegradable materials depends on different physiological parameters like pH or ion concentrations, the corrosion might be different in different biological environments. To investigate this issue, we produced screws from magnesium alloy AZ31 and implanted them into the hip bone of 14 sheep. After 3 and 6 months, the screws were explanted and analyzed with synchrotron-radiation based micro-computed tomography and hard tissue histology. We found considerable differences in the corrosion behavior of the magnesium screws with respect to its original tissue location. However, we could detect a normal immunological tissue response. (C) 2011 Elsevier B.V. All rights reserved.
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