Journal
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
Volume 176, Issue 20, Pages 1761-1766Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mseb.2011.06.006
Keywords
Stent; Mg release; Chandler-Loop; Static immersion test; Blood corrosion; Simulated body fluid (SBF)
Funding
- AiF [KF0548101PK7]
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Intravascular stents manufactured out of bioabsorbable magnesium (Mg) or Mg-alloys are considered as auspicious candidates for the next stent generation. However, before clinical application numerous physical and biological tests, especially to predict the clinically highly important degradation kinetics in vivo, have to be performed. In a Chandler-Loop model, the initial degradation of eight different magnesium alloys during 6h in contact with human whole blood was investigated. The magnesium release varied between 0.91 +/- 0.33 mg/cm(2) (MgAl9Zn1) and 2.57 0.38 mg/cm(2) (MgZn1). No correlation could be found with Mg release data obtained after immersion in simulated body fluid (SBF). This pilot study showed that Mg corrosion is highly influenced by the biological test environment (SBF or blood, etc.) and that a modified Chandler-Loop model with human whole blood may be superior to predict corrosion of Mg alloys under clinical conditions than the SBF models presently used. (C) 2011 Elsevier B.V. All rights reserved.
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