Journal
ACTA DIABETOLOGICA
Volume 52, Issue 4, Pages 773-779Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s00592-014-0699-3
Keywords
Type 1 diabetes; Vitamin D deficiency; Cardiovascular disease; Subclinical atherosclerosis; Coronary artery calcification; Carotid intima-media thickness
Categories
Funding
- Catalan Association of Diabetes
- Instituto de Salud Carlos III [PI12-00183]
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Several studies linked vitamin D deficiency with coronary artery disease (CAD). The aim of this study was to evaluate the relationship between the concentrations of 25-hydroxyvitamin D (25OHD) and the presence of early atherosclerosis in asymptomatic Type 1 Diabetes (T1D) patients with no previous history of ischemic heart disease. One hundred and forty-five patients with T1D (age 37.8 +/- A 8 years, 57 % male, all Caucasian, disease duration 20.6 +/- A 8.3 years, HbA1c 7.6 +/- A 1.4 % (60.2 +/- A 11.1 mmol/mol), body mass index (BMI) 25.2 +/- A 3.5 kg/m2, 52.4 % smokers, 23 % retinopathy, 10 % nephropathy) and 48 controls matched for age, sex, BMI and smoking habit were studied. 25OHD deficiency was defined for values a parts per thousand currency sign20 ng/mL. A sun exposure questionnaire, carotid ultrasonography to determine carotid intima-media thickness (CIMT) and the presence of atheroma plaques and cardiac computed tomography for evaluation of calcium artery calcification (CACS) were performed. T1D subjects showed a high proportion of 25OHD deficiency (43.2 % vs. 21.7 %, p = 0.032). Of all, 82 % of T1D patients and 92 % of controls had a calcium score of 0. CIMT was greater in patients with T1D (0.55 +/- A 0.14 mm vs 0.48 +/- A 0.15, p = 0.01) compared with controls. T1D subjects showed no differences in the results of CACS or CIMT according to the vitamin D concentrations. T1D patients have lower concentrations and twice more prevalence of 25OHD deficiency than controls. There was no association between 25OHD concentrations and subclinical CAD.
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