Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 93, Issue -, Pages 206-217Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.07.060
Keywords
Graphene magnetic nanoparticles; Magnetic hyperthermia; Controlled-drug release; Cancer therapy; Doxorubicin
Categories
Funding
- Associate Laboratory LSRE-LCM - FEDER through COMPETE2020 - Programa Operacional Competitividade e Internacionalizacao (POCI) [POCI-01-0145-FEDER-006984]
- FCT - Fundacao para a Ciencia e a Tecnologia
- RTChip4Theranostics [NORTE-01-0145-FEDER-029394]
- Programa Operacional Regional do Norte - Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF)
- Fundacao para a Ciencia e Tecnologia (FCT), IP
- FCT [SFRH/BD/97658/2013]
- FCT Investigator 2013 Programme [IF/01501/2013]
- European Social Fund
- Human Potential Operational Programme
- Slovene Research Agency [J2-6754]
- POCTEP (Co-operational Programme for Cross border Cooperation Spain-Portugal)
- COST (European Cooperation in Science and Technology) [TD1402]
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The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform for cancer therapy, exhibiting (i) an outstanding loading capacity of 91% (w/w, representing 910 mu g mg(-1)) of the chemotherapeutic drug doxorubicin, (ii) a high heating efficiency under an alternating (AC) magnetic field (intrinsic power loss ranging from 2.1-2.7 nHm(2) kg(-1)), and (iii) a dual pH and thermal stimuli-responsive drug controlled release (46% at acidic tumour pH vs 7% at physiological pH) under AC magnetic field, in just 30 (nth. Additionally, GYSMNP@PF127 presents optimal hydrodynamic diameter (D-H = 180 mn) with negative surface charge, high haemocompatibility for blood stream applications and tumour cellular uptake of drug nanocarriers. Due to its physicochemical, magnetic and biocompatibility properties, the developed graphene-based magnetic nano carrier shows high promise as dual exogenous (AC field)/endogenous (pH) stimuli-responsive actuators for targeted thermo-chemotherapy, combining magnetic hyperthermia and controlled drug release triggered by the abnormal tumour environment. The presented strategy and findings can represent a new way to design and develop highly stable added-value graphene-based nanostructures for the combined treatment of cancer.
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