Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 93, Issue -, Pages 921-930Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.08.063
Keywords
Triclosan; Polyurethane micelles; Lipase sensitive; Charge switchable; Bionirn
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Funding
- Applied Basic Research Programs Foundation of Sichuan Province [2015JY0126]
- Fundamental Research Funds for the Central Universities [2016NGJPY04]
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Three different kinds of polyurethane (PU) micelles, i.e. PEG-c-PU, PEG-g-PU and PEG-b-PU, with hydrophobic PCL core and hydrophilic PEG corona were prepared by self-assembly method. DLS studies illustrated that PEGg-PU micelles showed pH dependent surface charge switching properties while no obvious surface charge switching activities were found for PEG-b-PU and PEG-c-PU micelles. Triclosan was loaded into PCL core by dialysis method with pretty high encapsulate content and efficiency and the payloads were released at an accelerate rate in the presence of lipase. MIC and MSC studies demonstrated an enhanced antibacterial activity of encapsulated Triclosan against planktonic bacteria than free Triclosan. CISM images of S. am-eus biofilms treated with Nile red loaded PU micelles illustrated the penetration and accumulation of PEG-g-PU micelles inside the bacterial biofilms at an acidic environment. In addition, Triclosan loaded into PEG-g-PU micelles showed more potent antibiofilm activities than that loaded into PEG-c-PEG and PEG-b-PU micelles. Therefore, the PEG-g-PU micelles can be potentially used as hydrophobic antibiotic carriers to treat bacterial infections and biofilms.
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