Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 93, Issue -, Pages 1064-1072Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.08.064
Keywords
Hydrogels; Thermosensitive; Self-healing; Sustained release; Antitumor therapy
Categories
Funding
- National Natural Science Foundation of China, China [51472115, 81402859]
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions, China [PPZY2015B164]
- Administration of Traditional Chinese Medicine of Zhejiang Province, China [2017ZA075]
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In this study, we developed a self-healing thermosensitive gel, via dialdehyde-functionalized polyethylene glycol (DF-PEG) and beta-glycerophosphate (GP) cross-linked chitosan (CS) hydrogels, which enable autonomous self healing upon damage and sustained release of doxorubicin hydrochloride (DOX) for antitumor therapy via intratumoral injection. The cross-linked gels could exhibit sol-gel transition at 37 degrees C within 5 min and satisfactory in vitro and in vivo healing ability by observing the rejoining and fusion process of scratched gels. Moreover, the in vitro release of DOX loaded cross-linked gels in PBS (pH 6.5 and 7.4) was found to be extended to 13 d. After intratumoral injection in Heps tumor-bearing mice, the drug loaded self-healing thermosensitive gels showed a superior tumor inhibition rate (66.12%) than CS thermosensitive hydrogels (53.23%), while the histology studies gave the relieved cardiotoxicity and good biocompatibility of the cross-linked gels. Overall, these cross linked gels could become a potential local drug delivery system to achieve efficient sustained release, relieved side effects and enhanced therapy efficiency through localized administration.
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