Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 93, Issue -, Pages 679-685Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.08.035
Keywords
Silica quantum dots; Biological imaging; Luminescent nanomaterials; Mesoporous silica nanoparticles
Categories
Funding
- National Natural Science Foundation of China [51363016, 21474057, 21564006, 21561022, 21644014, 51673107]
- Natural Science Foundation of Jiangxi Province in China [20161BAB203072, 20161BAB213066]
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Silica quantum dots (SiQDs) and their luminescent composites have displayed great potential for biomedical applications owing to their chemical inert and low cost. In this work, we report a facile, cost-effective and ultrafast strategy to prepare a stable luminescent SiQDs using N-[3-(trimethoxysilyl)propyl]ethylenediamine (EDAS) and salicylaldehyde as precursors for the first time. These luminescent SiQDs were further utilized for fabrication of luminescent mesoporous silica nanoparticles (MSNs) through direct encapsulation of SiQDs by MSNs. The novel synthetic and modified SiQDs uses commercial raw materials and the entire reaction can be completed within 30 s. The successful preparation of SiQDs and SiQDs@MSNs were characterized by various characterization equipments. The cell viability as well as cell uptake behavior of SiQDs@MSNs were also examined to evaluate their potential for biomedical applications. We demonstrated that these SiODs@MSNs are low toxicity and of great potential for biological imaging. Based on the above results, we believe that these SiQDs@MSNs should be novel and promising candidates for biomedical applications owing to their intense fluorescence, biocompatibility and high specific surface areas.
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