Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 43, Issue -, Pages 280-289Publisher
ELSEVIER
DOI: 10.1016/j.msec.2014.07.027
Keywords
Direct laser writing; Two-photon polymerization; Microfabrication; Hydrogel; Polyamino acid; Poly(ethylene glycol) diacrylate
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Funding
- Finnish Cultural Foundation
- Doctoral Program of Tampere University of Technology's President
- TEKES (the Finnish Funding Agency for Technology and Innovation) Human Spare Parts project
- Czech Science Foundation [P108/11/1857]
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The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(alpha-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication. (C) 2014 Elsevier B.V. All rights reserved.
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