Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 43, Issue -, Pages 182-188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.07.026
Keywords
Porous Ti scaffolds; Stack sintering; Microporous Ti spheres; Centrifugal granulation
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Funding
- National Natural Science Foundation of China [81190131]
- National Key Technology Support Program of China [2012BAI18B04, 2012BAI17B01]
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Microporosity plays a key role in bioactivity and osteoinductivity of a biomaterial scaffold. A simple new approach to fabricating load-bearing porous titanium (Ti) scaffolds with uniform porous structure, highly controllable pore size and excellent biocompatibility was developed in the present study. This method was based on stack sintering of microporous Ti spheres produced with centrifugal granulation of commercial Ti powders. Macropores (180.0-341.8 mu m) and micropores (6.1-11.8 mu m) of the scaffolds were dependent on the sizes of the Ti spheres and the Ti powders, respectively. The compressive strength of the scaffolds (83.4-108.9 MPa) was high enough for the repair of load-bearing bone defects. Besides, the abundant micropores occurred on the rough and convex surface of the Ti spheres in the scaffolds were more favorable for adsorption of serum proteins, and thus promoted the growth of mesenchymal stem cells (MSCs). (C) 2014 Elsevier B.V. All rights reserved.
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