Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 45, Issue -, Pages 434-437Publisher
ELSEVIER
DOI: 10.1016/j.msec.2014.09.034
Keywords
Silver nanoparticles; Antimicrobial activity; Streptomyces coelicolor klmp33; Escherichia coli
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Funding
- University Grants Commission (UGC), New Delhi [42-487/2013 (SR)]
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The increasing emergence of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli (E. coli) occurred mainly due to continuous persistent exposure to antibiotics causing high morbidity and mortality so studies in controlling this infection are required. In the present investigation, we developed a synthesis for silver nanoparticles employing a pigment produced by Streptomyces coelicolor klmp33, and assessed the antimicrobial activity of these nanoparticles against ESBL producing E. coli. The ESBL producing E. coli were isolated from urine samples collected from the Gulbarga region in India. As can been seen. from our studies, the silver nanoparticles having irregular shapes and size of 28-50 nm showed remarkable antimicrobial activity and moreover the synthesis time is just 20 min and thus the same can be used for formulating pharmaceutical remedies. (C) 2014 Elsevier B.V. All rights reserved.
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